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Fig. 7. Enhanced cell proliferation in the mid- and rostral hindbrain of
Sp8-deficient embryos. (A-D) BrdU-labeled cells with a
pulse of 30 minutes are shown in frontal sections, at the level of the
posterior midbrain (A,B) and in sagittal hindbrain sections (C,D) of 10.5
wild-type and mutant embryos. In mutant embryos, a remarkable increase in the
number of proliferating cells was evident, thus suggesting that Sp8
negatively regulates cell proliferation. All images are at the same
magnification. A and B are 5 µm sections; C and D are 10 µm
sections.
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