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Fig. 8. Cell differentiation may be delayed at E11.5 in the absence of
Sp8. (A-D) Double-immunohistochemical analysis presenting
the expression of nestin (green) and ß-III-tubulin (Tuj1, red) as markers
labeling undifferentiated neuronal progenitors and differentiating neurons,
respectively. In Sp8 mutant embryos (E11.5), as indicated by the
arrowheads in B and D, there are some cells outside of the ventricular zone
that still express nestin but are devoid of Tuj1 signal. This suggests that
these cells might correspond to neuronal progenitors that are not fully
differentiated. C,D are at higher magnification than A,B.
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