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Figure 2


Fig. 2. Whole-mount and histological analysis shows decreased complexity of foliation in adult Gli2-En1 cko mutants. Cerebellar size is severely compromised along the anteroposterior (AP) axis in mutants, but the mediolateral extent is similar to wild type (A,D). Sagittal sections show fewer fissures in the vermis of the mutant (B,E). Some fissures in the mutant are barely detectable (arrows, E) and others are completely absent (asterisks, B). Horizontal sections highlight the similar mediolateral size of wild types and mutants; the mutant cerebellum is reduced in size along the AP axis (C,F, shown schematically in C',F'). The fissures in the mutant are much shallower than in wild type. Abbreviations: LS, lobulus simplex; CI, crus I; CII, crus II; PM, paramedial lobule.





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