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Fig. 6. Cell cycle genes Mycn and cyclin D1 (Ccnd1) are
downregulated in Smo-Nes cko and Gli2-En1 cko cerebella.
RNA in situ hybridization shows downregulation of the transcriptional target
of Shh, Gli1, in Smo-Nes cko mutants at E18.5 (A),
although expression of Math1 (B) indicates the presence of
GCPs. Another transcriptional target of Shh, Mycn, is downregulated
in Smo-Nes cko at E18.5 and Gli2-En1 cko mutants at P0,
respectively (E,G), compared with wild types (C).
Ccnd1, which is downstream of Mycn, is also downregulated
but still present in mutants (F,H) compared with wild types
(D).
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