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Figure 4


Fig. 4. Ephx652 mutant embryos lack obvious axon guidance defects in the embryonic CNS. View of the ventral nerve cord of stage 15-16 embryos in wild type (A,C,E) and Ephx652 mutants (B,D,F). (A,B) Embryos labeled with BP102 to visualize all axons. No obvious defects in axon guidance are detected in Ephx652 mutant embryos (B). (C,D) Staining with anti-Fas2 antibody, which labels five distinct axon bundles running anteroposteriorly on each side of the midline, three of which are in the plane of focus, is normal in Ephx652 mutants (D). (E,F) Embryos double-labeled for Fas2 (red) and for ß-galactosidase (green) driven by the expression of apC-tau-lacZ to visualize axonal projections of Ap neurons. Ap neurons extend axons (arrows) normally along the medial Fas2 bundle in Ephx652 mutants (F). Genotypes: (E) apC-tau-lacZ/+; Ephx652/+; (F) apC-tau-lacZ/+;Ephx652/Ephx652. Anterior is upwards for all panels.





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