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First published online April 12, 2006

Development 133, 905e (2006)
© The Company of Biologists Limited
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In this issue

New dimensions for Shh


Figure 1

The mid/hindbrain is an excellent model for studying 3D tissue patterning, but although its anteroposterior (AP) patterning is well characterised, dorsoventral (DV) patterning is not. Now, Blaess et al. (p. 1799) have used conditional mutagenesis to investigate how sonic hedgehog (Shh) directs DV patterning. Shh has two signalling modes involving the Gli transcription factors: in Gli2A-mediated Shh signalling, Shh converts Gli2 into a transcriptional activator; and in Gli3R-mediated Shh signalling, Shh opposes the processing of Gli3 into a repressor. The authors conditionally removed all Shh signalling (by mutating the receptor Smo) or just Gli2A-mediated Shh signalling (by mutating Gli2) at E9.0 or at E11.5 in the mouse mid/hindbrain. Gli2A-mediated signalling was needed early on for ventral patterning and for the dorsal restriction of Gli3 transcription. Gli3R-mediated signalling was important throughout for the development of dorsal structures and before E11 for regulating growth by inhibiting apoptosis. Gli3R-mediated Shh signalling also regulated the expression of the AP organiser Fgf8, leading the authors to conclude that Shh coordinates the AP and DV patterning of the developing mid/hindbrain.


Related articles in Development:

Sonic hedgehog regulates Gli activator and repressor functions with spatial and temporal precision in the mid/hindbrain region
Sandra Blaess, JoMichelle D. Corrales, and Alexandra L. Joyner
Development 2006 133: 1799-1809. [Abstract] [Full Text]  




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