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Fig. 8. Caspase-dependent PCD of Lbe-, Eg- and Eve-expressing cells.
(A-C) Lbe-positive cells, most likely from the NB5-3 lineage, are
present in higher numbers in H99 mutants (B) than in wt (A).
Apoptotic Lbe-positive cells can be seen at stage 14 (arrow in C).
(D-F) The Egexpressing NB7-3 lineage also shows too many cells in
H99 (E, compare with wt in D). The GW motoneuron undergoes apoptosis
in segments T3 to A8 at late stage 16 (arrows in F). (G-I) Eve-positive
U motoneurons are not present in segments A7 and A8 in wt embryos (G). In
H99, these cells survive (H). U neurons in A7 and A8 die at stage 14
(arrows in I). Lbe staining in C, Eg in F and Eve in I are in green, activated
Caspase-3 in red. A,B,D-H show late stage 16 embryos; C,I show stage 14
embryos. Lines in G-I demarcate segments A7 and A8 for clarity. Anterior is up
in all images.
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