|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
|
Fig. 1. Eda-A1 suppresses BMP activity in developing incisors. Whole-mount
in situ hybridization analysis of ameloblastin expression in E15 incisors
cultured with protein-releasing beads for 1 day. (A) Some endogenous
expression of ameloblastin is present in explants cultured with a BSA bead.
(B) Ameloblastin was strongly induced by a Bmp4-releasing bead.
(C) BSA-releasing beads (small and blue) were placed at the same time
with the Bmp4 bead (large and white). (D) Eda-A1 beads (blue) had no
major effect on Bmp4-induced expression of ameloblastin when applied
simultaneously with the Bmp4 bead (white). (E) BSA beads (blue) applied
6 hours before the Bmp4 bead (white) had no effect on ameloblastin expression.
(F) Introduction of Eda-A1-releasing beads (blue) 6 hours before the
BMP bead (white) strongly inhibited the induction of ameloblastin. (G)
The endogenous expression of ameloblastin was reduced in the presence of
Eda-A1 (compare with A).
|
