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Figure 7


Fig. 7. A schematic representation of the outcomes of Edar activation in primary hair follicles compared to signalling in secondary hair follicles. Upon ligand engagement, Edar activates NF-{kappa}B, resulting in the upregulation of Ccn2, follistatin and Shh expression. We suggest that Ccn2 and follistatin act locally to inhibit Bmps expressed in the epithelium and/or the condensed mesenchyme, thereby allowing the expansion of the nascent placode. After the placode stage, upregulation of Shh promotes invagination of the hair bud. In secondary hair follicles, noggin expressed in the condensed mesenchyme suppresses Bmp activity within the placode, whereas other signals, possibly Wnts, induce the expression of Shh.





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