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Fig. 2. Reduced fezl activity results in a deficit of the
prethalamus. (A,B) Severe deficit of dlx2a in the
prethalamus of a 28-hpf fezl morphant. Insets in A,B show unaffected
dlx2a expression in the pharyngeal arch (pa) area. Arrow in A
indicates dlx2a-expressing prethalamic cells; arrowhead in A indicates
dlx2a-expressing hypothalamic cells. (C,D) Reduction of
lhx5 in the prethalamic region of the fezl morphant. Arrows
in C,D indicate lhx5-expressing prethalamic cells; arrowhead in C,D indicates
lhx5-expressing posterior tubercular cells. (E-J) Expression of
foxg1 in the telencephalon (E-F), nk2.1a in the hypothalamus
(G-H) and six3b in the eye and optic stalk (I-J) are largely normal
in fezl morphants. (K-N) Reduction of dlx2a and
lhx5 expressions in 16-somite (16s) fezl morphants. Arrows
in K,L indicate the telencephalon and prospective diencephalon; arrow in M,N
indicates the prospective diencephalon. All are lateral views with specific
stages and marker identities indicted in each panel. di, prospective
diencephalon; hy, hypothalamus; pt, prethalamus; tel, telencephalon; os, optic
stalk.
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