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Figure 1


Fig. 1. Dusp6 expression correlates with particular Fgfrs and with most areas of dpERK expression. (A,D,G) Whole-mount RNA in situ hybridization (WmISH) of mouse embryos with the Fgfr probes indicated at the bottom right of each panel. (B,E,H) WmISH of embryos with a Dusp6 probe. (C,F,I) Whole-mount immunostaining of embryos with antibody directed against dpERK. Embryo age is indicated at the bottom left of each panel. (J-S) Transverse sections of E10-10.5 WmISH embryos illustrating potential FGF signaling pathways in the limb bud (J-O) and branchial arches (P-S). Probes are noted at the bottom left of each panel. ba, branchial arches; ec, ectoderm; lb, limb bud; mes, mesenchyme; mhb, midhindbrain junction; op, olfactory pit; ov, otic vesicle; so, somites. Scale bars: 100 µm in O for J-O; 100 µm in S for P-S.





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