Supplemental Figure 1
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Fig. S1. Transmission EM shows that normal ZCs develop from neck cells via transitional cells (TZ1 cells) with granules of mixed type. Cytoplasms of cells at the interface between the neck and base region are depicted. The basement membrane (bottom) and gastric unit lumen (top left) are shown by black, dashed lines. Notice that the mostly mucus-granule- (mucus granules are electron-lucent, labeled ‘MG’) containing cell at left, the cell with granules of mostly mixed/transitional type (chimeric pattern of partially electron-lucent, partially electron-dense; labeled ‘TG’) in the middle and a cell with mature zymogenic granules (electron-dense; labeled ‘ZG’) at right. Bottom: insets of boxes in the top panel. PC, cytoplasm of a parietal cell.
