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Figure 2


Fig. 2. Wnts associate with lipoprotein particles. Wnts associate with lipoprotein particles that may partially counteract the palmitate-mediated affinity of Wnt for cell membranes, thereby allowing the spreading of the protein further along the morphogenetic field. (A) This association could occur extracellularly. (B) Alternatively, as suggested by the potential sorting of Wnt to endosomes, the association of Wnt with lipoprotein particles may occur within the Wnt-producing cells, after endocytosis and the endosomal targeting of extracellular lipoprotein particles. Only a low fraction of Wnt binds lipoprotein particles, suggesting that long-range-acting Wnt may use a specialized secretion route, whereas short-range-acting Wnt may enter the constitutive secretion pathway.





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