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Fig. 3. Two models of the role of the retromer complex in Wnt maturation.
(A) The retromer may directly or indirectly bind a putative Wnt cargo
receptor in the TGN, directing the sorting of the Wnt-Wnt-cargo-receptor
complex to the endosomes for association with lipoprotein particles (left
panel). From the endosomes, the Wnt cargo receptors may either be recycled to
the Golgi or degraded in the lysosomes. In the absence of retromer function,
all Wnts enter the constitutive secretion pathway and exit the cells in their
short-range-signalling form (right panel). (B) The retromer complex may
retrieve the Wnt cargo receptors from the endosomes to the TGN, allowing the
further cycling of Wnt molecules (left panel). In the absence of retromer
function, the Wnt cargo receptors accumulate in the endosomes and are
eventually degraded in the lysosomes. A shortage of Wnt cargo receptors in the
TGN prevents the sorting of Wnts to the endosomes, resulting in constitutive
secretion of short-range-acting Wnts (right panel).
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