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Fig. 4. Production of a fully functional Wnt by Wnt-expressing cells. A
schematic of some of the different models proposed in this review. The steps
specific to the model where Wnt is secreted via the constitutive secretory
pathway and associates with lipoprotein particles outside of the cells are in
green. The steps specific to the specialized sorting route for endosomal
association with lipoprotein particles and secretion of long-range-signalling
Wnt are in red. The steps common to the two models are in black.