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Figure 4


Fig. 4. Outgrowth and skeletal patterning is not impaired in limbs devoid of Tbx5. Pregnant females were gavaged with TM at E8.5 (A,D,E), E9.5 (B,F,G) or E10.5 (C,H,I) and harvested 2 days later (A-C), at E14.5 (D,E) or at E16.5 (F-I). Embryos were stained for lacZ (A-C), or with Alizarin Red and Alcian Blue (D-I). (E,G) Skeletal preparations of FL from Prx1CreERT2;Tbx5lox/lox embryos gavaged at E8.5 or E9.5 showed abnormalities comprising a hole in the scapula, lack of the deltoid tuberosity (E,E'',G,G''; arrows) and pronounced elongation of digit 1 (E',G'; arrowheads). By contrast, skeletal preparations of Prx1CreERT2;Tbx5lox/lox embryos gavaged at E10.5 showed normal development (I).





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