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First published online December 12, 2006

Development 134, 104e (2007)
© The Company of Biologists Limited
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In this issue

Transport free Na,K-ATPase role at a junction


Figure 1

Cell junctions provide important adhesion, diffusion barrier, polarity and signalling functions during epithelial development. In Drosophila, claudin-containing septate junctions (SJs) provide a diffusion barrier and control the size of tracheal tubes. The formation of SJs requires the heterodimeric Na,K-ATPase ion transporter but not, as Paul and co-workers now report, its ion-pump activity (see p. 147). By investigating the localization and function of wild-type and chimeric isoforms of the single-transmembrane Na,K-ATPase ß-subunit, the researchers show that the extracellular domain of the Nrv2 isoform of this subunit is specifically required for both SJ functions. Similarly, only some isoforms of the ten-transmembrane {alpha} subunit, which contains the ATPase activity, support SJ function. Unexpectedly, mutations that inactivate the ATPase do not compromise SJ function, which indicates a pump-independent role for Na,K-ATPase in SJ formation and activity. Finally, because the rat {alpha}1 isoform completely rescues Atp{alpha}-null Drosophila mutants, the authors suggest that the Na,K-ATPase has an evolutionarily conserved role in epithelial junctions.


Related articles in Development:

A pump-independent function of the Na,K-ATPase is required for epithelial junction function and tracheal tube-size control
Sarah M. Paul, Michael J. Palladino, and Greg J. Beitel
Development 2007 134: 147-155. [Abstract] [Full Text]  




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