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First published online December 12, 2006

Development 134, 105e (2007)
© The Company of Biologists Limited
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In this issue

Foxa3: support signal from oocyte to follicle


Figure 1

During mammalian oestrous cycles, ovarian follicles support the development and release of oocytes. But this is not just one-way support, as oocytes also contribute to follicle development. On p. 199, Liu and colleagues report that oocyte-specific expression of the transcription factor Foxo3a negatively regulates oocyte growth and follicular development. The researchersÕ previous work had suggested that the suppression of Foxo3a in oocytes Ð through activation of the phosphatidylinositol 3-kinase pathway Ð might be needed for follicular development and oocyte growth. To test this idea, the researchers generated transgenic mice that express constitutively active Foxo3a in their oocytes. The female transgenic mice, they report, are infertile because of retarded oocyte growth and follicular development, and anovulation. They also show that constitutively active Foxo3a causes reduced oocyte-specific expression of proteins that are required for follicle development. Overall, the researchers conclude that Foxo3a is an important intra-oocyte signalling molecule and suggest that their results might provide clues to the causes of premature ovarian failure in humans.


Related articles in Development:

Infertility caused by retardation of follicular development in mice with oocyte-specific expression of Foxo3a
Lian Liu, Singareddy Rajareddy, Pradeep Reddy, Chun Du, Krishna Jagarlamudi, Yan Shen, David Gunnarsson, Gunnar Selstam, Karin Boman, and Kui Liu
Development 2007 134: 199-209. [Abstract] [Full Text]  




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