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Figure 10


Fig. 10. Loss of SEMA3A but not VEG164 affects sensory nerve branching in the mouse limb. (A-F) Visualisation of limb nerves at 13.5 dpc in wild-type forelimbs (Vegfa+/+; A,B) and forelimbs lacking VEGF164 (Vegfa120/120; C,D) or NRP1 (Nrp1-/-; E,F). Ventral (A,C,E) and dorsal (B,D,F) aspects of the forelimb are shown. Note that the delay in axon extension observed at 12.5 dpc (Fig. 8) is no longer apparent at 13.5 dpc. (G) Quantitation of sensory nerve branching in the dorsal footplate (i.e. above the grey line in B,D,F) of wild-type limbs (combined data for Vegfa+/+, Sema3a+/+ and Nrp1+/+; n=17) and limbs lacking VEGF164 (n=14), SEMA3A (n=5) or NRP1 (n=6).





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