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Figure 4


Fig. 4. Loss of heparin/neuropilin-binding VEGF isoforms, but not loss of SEMA3A, impairs brain vascularisation. Visualisation (A-F) and quantitation (G) of vessel branching in the subventricular zone of 12.5 dpc mouse hindbrains. PECAM-positive vessels are shown in a 0.25 mm2 area of littermate hindbrains with normal (Vegfa+/+) or reduced (Vegfa+/120 and Vegfa120/120) levels of heparin/neuropilin-binding VEGF isoforms (A-C), or in littermate hindbrains expressing (Sema3a+/+) or lacking (Sema3a+/-and Sema3a-/-) SEMA3A (D-F). (G) Quantitation of vessel branching in hindbrains lacking heparin/neuropilin-binding VEGF isoforms or SEMA3A in a CD1 or C57Bl/6 background. Wild types (Vegfa+/+ or Sema3a+/+), dark grey; heterozygous mutants (Vegfa+/120 or Sema3a+/-), light grey; homozygous mutants (Vegfa120/120 or Sema3a-/-), white. LOF, loss of function.





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