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Fig. 10. Dpp signaling regulates IPC morphogenesis in the Drosophila
pupal retina. Dpp signaling is required to achieve correct cell-cell
contacts, cell positions and cell shape during IPC patterning. This function
requires the activity of DE-cadherin (Cad) and Rho1 and is opposed by Rst.
This suggests that Dpp signaling acts as an intermediary or `third force'
between the Rst and DE-cadherin adhesion systems, providing a point of fine
and dynamic regulation of the adherens junctions during epithelial maturation.
A balanced interplay between these three systems is essential to regulate IPC
patterning during morphogenesis of the pupal retina. The placement of Rho1
after DE-cadherin is speculative. See text for details.