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Fig. 8. Dpp signaling works together with DE-caderin and Rho1 to pattern the
Drosophila pupal retina. (A,B) Removing one genomic
copy of shg and either tkv (A) or Mad (B) resulted
in a significant increase in the incidence of ectopic 2°/3°s (red
arrows) and misplaced 3°s (green arrows). Most misplaced 3°s were
accompanied by an extra cell; conversely, we observed many cases of extra
cells without a misplaced tertiary (red arrow). (C) Quantification of
2°/3°s defects. The data are expressed as the percentage of ommatidia
with defects out of the total number of ommatidia counted. n=number
of ommatidia counted from at least four different animals for each genotype.
(D,E) Removing one genomic copy of Rho1 in retinas
expressing four copies of tkv-IR enhanced the frequency and severity
of IPC patterning defects (arrows, compare D with E). The full genotypes were:
(D) GMR-gal4/+; UAS-tkv-IR2(2X)/+; UAS-tkv-IR1(2X)/+; (E)
GMR-gal4/+; UAS-tkv-IR2(2X)/Rho172F;
UAS-tkv-IR1(2X)/+.
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