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Fig. 7. Wnt-independent function of mesenchymal Pygo2 in lens development. (A) Quantification of lacZ-positive cells or total cells relative to control in the ocular mesenchyme of E8.5 mouse embryos of the indicated genotypes. The regions quantified are shown in Fig. 6E. ^*, P0.05>0.01. (B) Box plot showing the ratio of lens to optic cup diameter in E12.5 embryos of the indicated genotypes. ^**, P0.010. The wild-type control value incorporates the ten samples from Fig. 2K, 12 samples from the Fig. 3Q experiment that yielded the Wnt1-cre conditional mutants and a new set of four control values from this experiment that yielded the Wnt1-cre; ß-catenin conditional mutants. The germline null and Wnt1-cre conditional null values are reproduced from Fig. 2K and Fig. 5O, respectively, for the purposes of comparison. (C) Summary of cre expression patterns. Schematic of the right-hand side of E8.5 (top row) and E9.5 (bottom row) mouse embryos anterior to the midpoint of the optic vesicle. The green regions indicate the tissue domains in which the listed Cre drivers can perform allele conversions. om, ocular mesenchyme; op, optic pit; ov, optic vesicle; hse, head surface ectoderm. (D) Model for the involvement of Pygo2 in lens development (see text for details). Pax6^pp represents Pax6^pre-placode.

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