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Figure 2


Fig. 2. Alteration of GFAP expression in the developing and adult Olig2-ablated cortex. Expression of Gfap was analyzed by in situ hybridization on coronal brain sections of control (Olig2C/+;hGFAPCre or CtrlG) and Olig2 mutant mice (Olig2Cko;hGFAPCre or CkoG) at P7 (A,B), P14 (C-F) and adult (P79; G-J). Neocortical Gfap expression is indicated by blue arrows. Red, blue and white boxed areas in C,D and G,H, representing the hippocampus and the neocortex from control and Olig2-ablated mice, are shown at high magnification in E,F, and I,J, respectively. Arrowheads and arrows in E,F indicate Gfap expression in the white matter tract and stratum lacunosum-moleculare of the hippocampus, respectively. Cortical lamination layers are indicated on the right-hand side of D.





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