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Figure 7


Fig. 7. CaMKII inhibition suppresses LR defects induced by altered Ca2+ levels. (A) Confocal imaging of Calcium Green in blastomeres of control zebrafish embryos (left) and those injected with {alpha}2-MO (middle) and Ncx4a-MO (right). The upper panels show the original fluorescent images and the lower panels are false-colored to highlight the increased Ca2+ levels in {alpha}2 and Ncx4a morphants. (B) CaMKII mediates Ca2+ signaling in LR patterning. Bar chart shows the percentage of embryos exhibiting LR patterning defects. Treatment with the CaMKII-inhibitor KN62 is able to block LR patterning defects induced by {alpha}2-MO, Ncx4a-MO, A23187 or thapsigargin.





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