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Fig. 4. BioTapestry models of Hh-driven cis-regulatory networks in mouse.
Transcriptional targets of the Hh pathway can be defined by a globally
responsive signaling cassette (A), containing components that are
either known (unbroken lines) or likely (broken lines) to be part of a
negative feedback loop. (B) A model for a Shh-driven transcriptional
network underlying ventral neuronal specification. In this diagram, depicted
in standard BioTapestry nomenclature
(Longabaugh et al., 2005),
neuronal specification is depicted as a sequential series of cell states. All
genes not expressed are in gray, whereas currently expressed genes are in
black or other colors. Similarly, inactive links (active in previous stages of
specification) are depicted in gray, whereas active activation or repression
is depicted using lines of other colors. An animation of these events can be
viewed in Movie 1 in the supplementary material. This diagram focuses
explicitly on ventral cell specification; thus previous events in general
neuronal specification are not shown. Validated Gli targets (all identified or
confirmed in our study) are indicated by blue diamonds (ChIP peak), orange
diamonds (transgenic validation) or green diamonds (mutation of binding site
in transgenic embryos).
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