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Figure 2


Fig. 2. Loss of Foxp2 leads to postnatal lung alveolarization defects. (A-F) Hematoxylin and Eosin staining of wild-type and Foxp2-/- mutant mice revealing dilated airspaces in the Foxp2 mutant lungs at E18.5, P8 and P20. (G) Mean linear intercept (MLI) calculation of wild-type and Foxp2 mutant lungs at the indicated times showing airspace enlargement in Foxp2 mutant mice. (H,I) TEM of wild-type (H) and Foxp2 mutant lungs (I) does not reveal a significant change in alveolar epithelial morphology at P8. Scale bars: 500 µm in A-F.





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