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Figure 8


Fig. 8. Model of salivary gland migration in Drosophila. (A) As the salivary glands invaginate into the embryo during stage 12 they are attracted to the CVM by Netrin. The salivary glands also encounter both attractive (Netrin) and repulsive (WNT4 and Slit) signals from the CNS, which guide the salivary glands during their posterior migration. The receptors for these early signals are present throughout the entire salivary gland and appear to work, for the most part, independently of each other. (B) During stage 15, the salivary glands meet the LVM and rely on the WNT5 repulsive signal from the CNS to keep the distal tip of the salivary gland positioned so it can adhere to the longitudinal visceral mesoderm. This is accomplished through Derailed, which is present specifically in the cells at the tip of the salivary glands.





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