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Fig. 4. Global appearance of LGE fate in Shh^N/- telencephalic neuroepithelium at later developmental stages. (A-D) E13.5 control (A-B) and Shh^N/- (C-D) mouse coronal sections immunostained with LGE marker, Gsh2 or Mash1 as indicated. Aa and Ca are higher magnifications of the boxed regions in A and C, respectively. (E-Hc) E15.5 control (E-F) and Shh^N/- (G-Gc,H-Hc) coronal sections stained with Gsh2 or Mash1 antibody as indicated. Ea-c, Ga-c and Ha-c are higher magnifications of the boxed regions in E, G and H. At E13.5, ectopic Gsh2 or Mash1 expression in Shh^N/- is restricted to the dorsal midline (Ca,D). By E15.5, ectopic LGE marker expression was also detected in the neocortex region (Gb,Hb, arrows). (I-Ja) Gli3 expression in E13.5 control and Shh^N/- telencephalon. (I,Ia) Strong Gli3 expression was detected in control telencephalic cortex and LGE, weak expression was present in MGE, and no Gli3 expression was detected in cortical hem and developing choroid plexus. (J,Ja) Gli3 expression was prominent along the dorsoventral axis of the Shh^N/- telencephalon, but selectively absent in the dorsal midline. MGE, medial ganglionic eminence; LGE, lateral ganglionic eminence; ncx, neocortex; st, striatum; tCP, telencephalic choroid plexus.

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