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Figure 6


Fig. 6. Dorsoventral patterning is largely unperturbed in ShhN/- spinal cord. (A-L) Cross-sections of E10.5 control (A,C,E,G,I,K) and ShhN/- (B,D,F,H,J,L) mouse spinal cord stained with the indicated markers of neural progenitors and differentiated neurons at the branchial level. Nkx6.1 is expressed in the broad ventral domains encompassing the p3, pMN and p2 progenitor domains. Olig2 is selectively expressed in the pMN progenitor domain. Pax7 is expressed in all dorsal progenitor domains. The domain that is negative for Pax7 and Nkx6.1 represents the p0 and p1 progenitor domains (brackets in A,B). (M) Quantification of Pax7, Nkx6.1 and p0+p1 progenitor domain size as a percentage of total dorsoventral (D-V) length of the neural tube. (N,O) Quantification of total numbers of cells in the FP (Foxa2+), pMN (Olig2+), p3 (Nkx2.2+), MN (Isl1+), V2 (Chx10+) and V1 (En1+) domains in the wild type and ShhN/-.





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