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Fig. 4. Gene expression of cartilage-to-bone-associated genes and the formation
of primary spongiosa are inhibited in Kif3a-deficient
synchondroses. (A,F) Parasagittal serial sections of P7
control (A) and mutant (F) spheno-occipital synchondrosis were stained with
fast green/Safranin O to reveal bone tissue (dark blue). Notice the marked
reduction of primary bone spongiosa in mutant tissue (F), which is highly
visible in controls (A, arrowheads). (B-E,G-J) Expression of the
indicated genes as revealed by in situ hybridization with serial sections of
control (B-E) and mutant (G-J) tissue. The hybridization signal was given
artificial colors and images were superimposed with hematoxylin histologic
images of the corresponding field. Scale bar: 80 µm in E for A-J.
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