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Figure 5


Fig. 5. Hand2 deletion does not prevent the colonization of the bowel by enteric nervous system precursor cells in vivo but interferes with their development as neurons. (A-C) Sox10+ (green, A), Phox2b+ (red, A) and p75NTR+ (green, B) cells are present and similarly distributed in the stomachs and small intestines of E12 wild-type (WT) and Wnt-1-CreH2{Delta} mice; (C) quantified data. (D) p75NTR+ (green) and Hu+ (red) cells in the stomachs of Wnt-1-CreH2{Delta} mice (right) and wild-type littermates (left). p75NTR is present, but Hu is virtually absent, in Wnt-1-CreH2{Delta} mice. (E) The densities of Hu+ cells at E12 in the stomachs and small intestines of Wnt1-CreH2{Delta} are lower than those in the stomachs and small intestines of wild-type mice. (F) The densities of Hu+ cells in the neural tubes and dorsal root ganglion (DRG) of E12 Wnt-1-CreH2{Delta} mice and wild-type mice are similar. ns, not significant. Scale bars: 50 µm.





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