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Figure 5


Fig. 5. The regionalization of the primitive streak and the specification of the mesoderm are partially maintained in murine Fgf8{Delta}b-neo/{Delta}b-neo embryos. (A-L) In situ hybridization analysis of markers (indicated to the left) characteristic for Fgf8 signaling and mesoderm in wild-type and Fgf8{Delta}b-neo/{Delta}b-neo embryos at E7.5. (A-D,I,J) Adjacent sagittal sections of wild-type (A,C,I) and Fgf8{Delta}b-neo/{Delta}b-neo (B,D,J) embryos. Inset in B shows whole-mount analysis of Fgf8 expression. Notice that axial mesoderm marked by T and Foxa2 expression is absent anterior to the streak of Fgf8{Delta}b-neo/{Delta}b-neo embryos, indicating a lack of mesoderm migration. (E,F) Asterisk indicates Evx1 expression at the proximal end of the primitive streak.





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