spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

Right arrow Help viewing high resolution images
Right arrow Return to article
(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.


Figure 3


Fig. 3. Time-lapse imaging of migrating neurons expressing either CAG-EGFP or CGC-Cdk5-DN. (A) Representative results are shown for mouse brain slices electroporated with either CAG-EGFP (GFP) or CGC-Cdk5-DN (Cdk5-DN) at E14.5. (B) Based on their morphology and behaviour, GFP-positive neurons were divided into two categories: bipolar shape (bipolar) or multipolar shape (multipolar) when observed at 4 hours (4 h) and 24 hours (24 h) post-electroporation, and the percentage of each is shown for CAG-EGFP and CGC-Cdk5-DN brain slices. (C) The percentage of GFP-positive neurons that transformed from multipolar to bipolar during a 20-hour peroid was calculated for each slice and subjected to statistical comparison. Multipolar-to-bipolar transformation was impaired in neurons expressing Cdk5-DN (GFP, 40.15±14.25%; Cdk5-DN, 7.75±3.77%, n=4); *, P<0.001.





Right arrow Return to article