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Fig. 4. Viable En1 and En2 double-mutant adult mice have
midbrain and cerebellar defects. (A-D) Dorsal posterior views of
adult brains of (A) wild-type, (B) En2-/-, (C)
En1-/+;En2-/+ and (D)
En1-/+;En2-/- mutant mice. (E-L) Cresyl
Violet-stained sagittal sections of the cerebella shown in A-D at the level of
the vermis (E-H) and hemispheres (I-L), as indicated in A by the red and black
dashed lines, respectively. Black and red arrowheads indicate the anterior and
posterior foliation defects, respectively. Blue and red asterisks indicate
hemisphere foliation defects and truncation in the IC, respectively. See
Fig. 2 legend for midbrain and
cerebellum annotation.
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