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Fig. 6. mes and r1 cells behave differently in
En1-/+;En2-/- mutants. (A-J)
Tamoxifen was administered to mouse embryos carrying the indicated alleles at
18.00 h on E10.5. (A,B) Coronal sections of E12.5 brains and (C,D) horizontal
and (E,F) midline sagittal sections of E16.5 brains stained for ß-gal
activity. (G,H) Dorsal views of ß-gal-stained adult brains. (I,J)
Sagittal sections of adult brains taken at the level of the vermis and stained
for ß-gal. The domain of marked cells was comparable in the
En1CreERT1/+;En2-/- and
En1CreERT1/+;R26R/+ embryos at E12.5, but decreased in the
tectum and increased in the Cb of
En1CreERT1/-;En2-/-;R26R/+ embryos by E16.5.
CbP, cerebellar primordium; EGL and associated bar, external granule layer.
Ist, isthmus; Mb, midbrain; VZ, ventricular zone; A, anterior; P, posterior;
M, medial; L, lateral. Red asterisks indicate truncation of the
isthmus/inferior colliculus. CbP is outlined by a purple dashed line in C,D;
in I,J, the IC and SC are outlined by dashed red and green lines,
respectively. The red bar in A,B indicates the size of the CbP domain with
marked cells.
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