spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

Right arrow Help viewing high resolution images
Right arrow Return to article
(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.


Figure 7


Fig. 7. Model for integrin/Cas-mediated regulation of axonal fasciculation. (A) During axon pathfinding, integrin/Cas signaling (+) functions to regulate axon-axon fasciculation. In this model, integrin/Cas-mediated adhesive interactions are strongest at choice points, slowing axons so that they can navigate specific defasciculation events. (B) Removal of integrin or Cas adhesive signaling in a loss-of-function (LOF) mutant background prevents axons from defasciculating at their choice points, maintaining fasciculation with the main axon bundle. (C) Neuronal overexpression (gain-of-function, GOF) of Cas increases integrin/Cas adhesive signaling and also prevents axons from defasciculating at their choice points. This model suggests that integrin/Cas adhesive signaling is necessary for axonal defasciculation but is not sufficient, such that other guidance cues, including axonal repellents, coordinately work together with integrin/Cas signaling to direct specific axon defasciculation.





Right arrow Return to article