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Figure 4


Fig. 4. Blocking Notch signalling reduces the expression of Sox2 and Bmp4. (A-D) Whole-mount view of stage HH12 embryos cultured for 24 hours in control (A,C) or DAPT-supplemented (B,D) medium. All panels are dorsal views (anterior left). (A) Sox2 is expressed throughout the early otic epithelium of control embryos, sometimes with an increased expression in the anterior and posterior regions of the otic cup. (B) In DAPT-treated embryos, Sox2 expression is greatly decreased in the otic cup, as it is in the neural tube. (C) Bmp4 is expressed in control embryos in the posterior rim of the otic cup and in a small patch in the anterior part (arrows). (D) After DAPT treatment, Bmp4 expression in the otic epithelium is greatly diminished.





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