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Fig. 5. Patterns of cell movement demonstrate differential requirements for two
discrete phases of cardiac fusion in zebrafish. (A) Cardiac fusion
begins with a phase of medial cardiomyocyte movement (red arrows). Cardiac
cone formation is facilitated by a second phase of regionally restricted
angular movement (yellow arrows). (B) In the absence of endocardium, as
in clo mutants, medial movement proceeds, but angular movement is
lost, resulting in a dysmorphic cardiac cone. (C) In cardia bifida
mutants such as mil, medial movement is lost, but angular movement
proceeds, resulting in the formation of bilateral cardiac cones. (D) In
mil;clo double mutants, all cardiomyocyte movement is lost,
indicating a requirement for endocardium for induction of the angular movement
observed in mil mutants.
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