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Figure 6


Fig. 6. Genetic inactivation of one copy of the Bmp4 gene in a Grem1 mutant background rescues the kinetics of ureteric epithelial growth and branching. Left panels: GFP reveals the morphology of the epithelium before fixation. Right panels: whole-mount in situ detection of the expression of the Ret receptor (A-C,G-I) and the Gdnf ligand (D-F,J-L). (A,D,G,J) Wild-type metanephric primordia. (B,E,H,K) Grem1 (G1{Delta}/{Delta})-deficient metanephric primordia. Note the complete disruption of ampulla formation (E,H,K) and loss of mesenchymal Gdnf expression (K), whereas Ret expression remains in the arrested epithelium (H). (C,F,I,L) Metanephric primordia of G1{Delta}/{Delta}; B4{Delta}/+ mouse embryos. Note the rescue of ureteric epithelial outgrowth (C), branching (F,I,L) and propagation of Gdnf expression (L).





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