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Fig. 2. Aberrant OSN projections in Ac3-null mice. (A-F) Whole-mount
analysis of P15 Omp-lacZ bulbs in which all mature OSNs are
stained blue. (A,B) Control and Ac3-/- mice, respectively. A clear
reduction in the number of caudal glomeruli is observable in the mutant when
compared with the control. (C,D) Dorsal view of the olfactory bulb of two
animals. (E,F) Corresponding dorsal view of Ac3-/- animals,
revealing a drastic reduction of dorsocaudally located glomeruli. Arrows
indicate the position of necklace/Grueneberg glomeruli, the organization of
which appears affected in the mutants. (G,H) Sagittal sections
of control (G) and Ac3-null (H) P15 mice. Omp is stained in green. The
complete lack of caudal Omp-positive glomeruli on the dorsal part of the bulb
is clearly visible. Inserts correspond to high magnifications of wild-type and
Ac3-/- dorsorostral glomerular layers, and show a glomerular
disorganization in Ac3-/- animals. Scale bars: 0.5 mm. AOB,
accessory olfactory bulb; C, caudal; D, dorsal; L, lateral; M, medial; MOE,
main olfactory epithelium; OB, olfactory bulb; R, rostral; V, ventral; VNO,
vomeronasal organ.
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