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Figure 5


Fig. 5. Altered structure and non-exclusive innervation of glomeruli in Ac3-/- glomeruli. (A,B) Sagittal sections through olfactory bulbs of P17 Ac3-/- MOR23 and M72 homozygous mice. Arrows indicate the presumed external glomerular limits, which are difficult to identify due to the loose ensheathing of the glomeruli by periglomerular cells. The glomerular structures are irregular, and the glomeruli corresponding to M72 and MOR23 are innervated by fibers stained with NCAM (in red) that do not express M72 or MOR23. Control sections of wild-type glomeruli innervated by MOR23 (C) or M72 fibers show exclusive innervation and regular structure of the glomeruli (data not shown) (Feinstein and Mombaerts, 2004; Vassalli et al., 2002). Scale bars: 100 µm. OB, olfactory bulb.





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