spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

Right arrow Help viewing high resolution images
Right arrow Return to article
(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.


Figure 5


Fig. 5. Mef2 controls a transcriptional module involved in thick filament assembly. In situ hybridisation for mRNAs encoding sarcomeric components in 24-hpf control or mef2d/c MO-injected zebrafish embryos. In each panel, cryosections of wholemount embryos, dorsal up, are to the left and flatmounts, anterior up and dorsal to right, are to the right. (A-D) Embryonic fast myhz1 (B), mylz2 (C, 22s) and smbpc (D) mRNAs are grossly downregulated in morphants. Slow fibre-specific smyhc1 mRNA (A) remains abundant. (E-G) mRNA for thin filament-related genes detected with probes to acta1 (E, 21s) or tnnc (G) are unaltered in morphants, whereas tpma (F) is upregulated. Note the lack of change in nuclear Pax3/7 protein (F, brown). (H) mRNA for the myosin chaperone protein hsp90a is also upregulated.





Right arrow Return to article