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Figure 6


Fig. 6. Activated Wnt/ß-catenin signaling in renal vesicle progenitor cells in mice is sufficient to induce mesenchymal induction markers in the absence of Wnt9b. (A-P) Whole-mount in situ hybridization at E12.5. (A,E,I,M) HoxB7 and (B-D,F-H,J-L,N-P) the mesenchymal induction markers (Fgf8, Wnt4 and Lhx1) on E12.5 embryonic kidneys. The mesenchymal induction markers are not detected in kidneys from Wnt9b mutants (F,G,H) and ectopically expressed when Wnt/ß-catenin pathway is activated by Six2TGC (J,K,L). Six2TGC-mediated activation of Wnt/ß-catenin pathway also causes ectopic expression of the mesenchymal induction markers in Wnt9b mutants (N,O,P).





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