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First published online June 11, 2007

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In transitin with Numb

Neurons and glia are generated in the developing CNS following asymmetric divisions of neural stem cells in the neuroepithelium - the cleavage plane is reportedly important for the localisation of cell-fate determinants. On p. 2425, Wakamatsu et al. report that in chicks, transitin, an intermediate filament protein, physically interacts with Numb, a cell-fate determinant, anchoring it to the cell cortex of mitotic neuroepithelial (NE) cells. Using biochemical, overexpression and RNAi-knockdown assays, these researchers show that transitin and Numb physically interact in the chick NE cell cortex. Cell-tracing experiments reveal that the lateral movement of this basally located transitin-Numb complex - which occurs by an unknown mechanism - asymmetrically localises Numb to one daughter cell, even when the cleavage plane is perpendicular to the ventricular surface. Interestingly, transitin gene knockdown in NE cells reduces the levels of basally located Numb and also promotes cell differentiation. Future work will probably focus on the mechanism by which transitin mediates both cellular differentiation and the lateral movement of Numb.

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Related articles in Development:

Transitin, a nestin-like intermediate filament protein, mediates cortical localization and the lateral transport of Numb in mitotic avian neuroepithelial cells

Yoshio Wakamatsu, Noriko Nakamura, Ju-Ahng Lee, Gregory J. Cole, and Noriko Osumi
Development 2007 134: 2425-2433. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?