QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

First published online June 11, 2007

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?

Notching up gliogenesis

Constitutive Notch (N) overexpression promotes gliogenesis, but does this reflect the true physiological role of N signalling? To answer this question, Sean Morrison's group conditionally deleted Rbpsuh - which encodes the DNA-binding protein RBP/J and is required for canonical signalling by all N receptors - in the mouse central (CNS) and peripheral (PNS) nervous systems. Their results on p. 2435 show that N signalling regulates gliogenesis independently of its role in neural progenitor maintenance. The conditional deletion of Rbpsuh in neural crest stem cells and in neuroectodermal cells of the developing CNS causes a near complete loss of gliogenesis, despite neurogenesis occurring almost as normal. These defects, the authors show, are not due to the premature depletion of neural progenitors. Rbpsuh, the authors report, is also required to maintain Sox9 (a glial specification gene) expression in spinal cord progenitors, demonstrating that N signalling acts in glial specification. Together, these findings reveal a reiterative role for N signalling in neurogenesis; initially promoting progenitor maintenance and later promoting gliogenesis.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

Related articles in Development:

Physiological Notch signaling promotes gliogenesis in the developing peripheral and central nervous systems

Merritt K. Taylor, Kelly Yeager, and Sean J. Morrison
Development 2007 134: 2435-2447. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?