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Figure 10


Fig. 10. Schematic representation of bone formation in calvaria. Bone formation is a multistep process that requires an initial condensation stage. In this step, which enables the cells to start the differentiation process, early markers such as RUNX2 and osterix (also known as SP7) are expressed. At later stages, other osteogenic markers such as BSP, osteocalcin (also known as BGLAP) and osteonectin are produced. Lack of ICAP-1 expression slows down proliferation and the ability of mesenchymal cells to compact. Since the compaction is a very early event in the osteoblast differentiation pathway, the expression of more-distal markers is consequently reduced in Icap-1-/- mice.





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