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Fig. 2. Growth delay, craniofacial malformation and delayed bone mineralization
in Icap-1-deficient mice. (A) Gross appearance of
Icap-1+/+ and Icap-1-/- P0
littermates. Note that Icap-1-/- mice are smaller in size
than their control littermates. A subset of the Icap-1-/-
offspring has an empty stomach (arrow). (B) Growth curves of control
(Icap-1+/+ or Icap-1+/-) versus
Icap-1-/- (male and female) offspring of two pooled
representative littermates. Mice were weighed every other day over a period of
34 days. Each point represents the mean±s.d. (C) Lateral view
(upper panel) or top view (lower panel) of 30-day-old wild-type and
Icap-1-deficient mice. Note the abnormal shape (short nose and
bulged-head) of the Icap-1-deficient skull compared with the wild
type. (D) X-ray analysis of Icap-1+/+ and
Icap-1-/- 5.5-month-old mice. Note that in the
Icap-1-null mouse the skull shape is severely affected, long bones
are shorter and vertebrae are only poorly ossified (arrows and insets for
higher magnification). (E) Alizarin Red/Alcian Blue staining of E16.5
skeletons showing reduced Alizarin Red staining intensity of the maxilla
(arrowheads), the radius and ulna of the forelimb (arrows) in
Icap-1-null tissues. (F) Alizarin red/Alcian Blue skeletal
staining at newborn stage. No obvious difference in staining intensity or
patterning could be seen between the two genotypes.
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