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Figure 4


Fig. 4. Epigenetic reprogramming and transcriptional quiescence are independent of Nanos3 function in mice. H3K9me2 (A), H3K27me3 (B), H3K4me2 (C) and Ser2 phosphorylation (D) (red, middle columns) in wild-type (+/+) (top row) and Nanos3-null (-/-) (bottom row) PGCs (green, left columns). Merged images with Hoechst staining (blue) are shown in the right columns. Percentages of H3K9me2-reduced (A), H3K27me3-elevated (B), H3K4me2-normal (C) and H5-negative (D) PGCs are indicated with the number of cells analyzed in parenthesis. Scale bar: 10 µm.





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