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Fig. 8. Depletion of Xflop or LPA receptors causes reduced C-cadherin expression
and reduced cortical actin assembly that can be rescued by C-cadherin
mRNA. (A-C') Pairs of images (left, C-cadherin staining;
right, F-actin staining) from Xenopus embryos that were untreated
(A), Xflop-depleted (B), or LPA1 and LPA2-depleted (C). Both cadherin staining
and cortical actin assembly are reduced by Xflop and LPA1/2 depletion. The
effects of each depletion can be rescued by subsequent injection of
C-cadherin mRNA (B',C'). (D,E) Cortical
actin levels were quantitated by pixel intensity. *,
P<0.01. Insets are western blots showing that depletion of Xflop
(D) or LPA1/2 (E) receptors also reduced the total levels of C-cadherin.
tubulin was used as a loading control. Scale bars: 10 µm.
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